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Tracking Cancer Signalling
Recent work demonstrates that receptors transmit information not only from the cell surface but also from inside the cells, on endosomes. The aim is to understand how receptor tyrosine kinases (RTK) transmit information inside the cell and why intracellular RTK activity is required for optimal cell behaviour. This project will apply engineering technology for the automatic imaging, quantification, and modelling of RTK “endosomal signalling” in human cancer cells and tissues, combined to biochemistry and functional assays including cell migration, proliferation and survival. Novel technologies measuring and modeling receptor endosomal signalling will be generated, enhancing basic knowledge of receptor signalling.
Disciplines and Techniques
Project supervisor/s
Dr. Stéphanie Kermorgant
Stéphanie's research involves the role of growth factor receptor signalling and intracellular trafficking (movement inside cells) in tumour growth and metastasis in the view of improving cancer therapy.
Queen Mary University of London
Dr. Paul Fromme
Paul Fromme's research interests lie in the application of ultrasonic waves for nondestructive testing and structural integrity monitoring.
University College London
References
A direct role for Met endocytosis in tumorigenesis
Nature Cell Biology , 13:827-37
2011
Receptor Tyrosine Kinase c-Met controls the cytoskeleton from different endosomes via different pathways
Nature Communications 5:3907
2014
Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes
Nature Communications 7:11942
2016
Met Endosomal Signalling: In the right place, at the right time
Int J Biochem Cell Biol, 49:69-74
2014
Receptor trafficking controls weak signal delivery: a strategy employed by c-Met for STAT3 nuclear accumulation
J Cell Biol, 18:855-63
2008