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Synthetic community [SynCom] transfer for the restoration of disrupted beneficial phyllosphere microbiomes


Abstract We have shown that the plant immune response causes a dramatic disturbance of the above- ground “phyllosphere” microbial community. Functional modelling of the impact of this change predicts a negative cost to plant health as a result. This project aims to test this impact, examining disease resistance in the crop plant, Brassica rapa, in which immune pathways are triggered through hormone application, and to examine the effects of SynCom supplementation via the application of either representative beneficial or disrupted microbial communities. The ultimate goal would be the development of a complementary agricultural solution for microbiome restoration following disease outbreak.

Disciplines and Techniques
Project supervisor/s
Paul Devlin
Biological Sciences (
Royal Holloway University of London
Dr Ken Bruce
Molecular Microbiology (
King's College London
The airways microbiome of individuals with asthma treated with high and low doses of inhaled corticosteroids
Martin, M. J., Zain, N. M. M., Hearson, G., Rivett, D. W., Koller, G., Wooldridge, D. J., Rose, G., Gharbia, S. E., Forbes, B., Bruce, K. D. & Harrison, T. W.
PLoS ONE. 15, e0244681
Amoebae in Chronic, Polymicrobial Endodontic Infections Are Associated with Altered Microbial Communities of Increased Virulence
Koller, G., Foschi, F., Witherden, L., Mitchell, P., Bruce, K. & Mannocci, F.
Journal of Clinical Medicine
Lung function and microbiota diversity in cystic fibrosis
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Microbiome. 8, 1, 45
Soil Inoculation With Bacillus Spp. Modifies Root Endophytic Bacterial Diversity, Evenness, and Community Composition in a Context-Specific Manner
Gadhave K..R*, Devlin P.F.*, Ebertz A., Ross A. & Gange A.C.
Microbial Ecology 76:741
Improvement in Hepatic Encephalopathy with Rifaximin Is Associated with Distinct Changes in the Metagenomic Species in the Saliva and Stool Microbiome and a Reduction in Systemic Inflammation - Results of the Rifsys Randomized Controlled Trial
Patel, V. C., McPhail, M. J., Zamalloa, A., Stoy, S., Vijay, G. K. M., Witherden, E., Lee, S., Shoaie, S., Huang, X., Rogers, G., Choo, J., Zia, R., Edwards, L., Gray, E., Woodhouse, C. A., Gencer, S., Cohen, M., Wendon, J., Erhlich, S. D., Bruce, K. & S
Hepatology 68, 6, 1462A-1463A