Sphingolipid Polar Heads: Hydrogen Bonding and Hydration

Sphingolipid behaviour is critical in cell regulation and signaling, and it is believed to depend on interactions within and between sphingolipids’ polar heads, and with water. However, there are virtually no investigations of the interactions established by sphingolipids with atomic resolution. This project aims to elucidate these interactions by using a combination of synthetic, spectroscopic and molecular modelling methods.

Disciplines and Techniques

Project supervisor/s

Dr. Maria Eugenia Sanz

Maria is interested in understanding the structural preferences of biologically relevant molecules and how these preferences are affected by interactions with other molecules.

King's College London

Dr. Chris Lorenz

Chris is interested in applying state-of-the-art molecular dynamics simulation methods to a variety of interesting and impactful research areas.

King's College University

References

Principles of bioactive lipid signalling: lessons from sphingolipids

Y. A. Hannun, L. M. Obeid

Nat Rev. Mol. Cell Biol. 9, 139

2009

Intramolecular interactions in the polar headgroup of sphingosine: serinol

D. Loru, I. Peña, J.L. Alonso, M. E. Sanz

Chem.Comm., 47, 6216

2016

Conformational Flexibility of Limonene Oxide Studied By Microwave Spectroscopy

D. Loru et al.

ChemPhysChem, 18, 274 ), cover

2017

Unknown

R. J. Gillams, C. D. Lorenz, S.E. McLain,

J. Chem. Phys. 144, 225101

2016

Unknown

R. J. Gillams, J. V. Busto, S. Busch, C. D. Lorenz, S. E. McLain,

J. Phys. Chem. B 119, 128-139

2015

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Sphingolipid Polar Heads: Hydrogen Bonding and Hydration