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Does Intensification of Poultry Production Impact on Campylobacter Evolution, Microbiome Variation and the Risk of Antimicrobial Resistance?

Richard Stabler Researxh image

The global burden of the foodborne disease Campylobacteriosis is substantial, with the greatest risks linked to chicken meat. Chicken is the most popular global source of animal protein, but intensification of production has relied on the overuse of antibiotics, creating conditions for generation and dissemination of antibiotic resistant bacteria threatening human health. We will work alongside the GCRF One Health Poultry Hub using Campylobacter isolates collected from four LMIC countries with complementary microbiome, metagenomics and antimicrobial residues data to investigate the effect of intensification on bacterial occurrence and evolution, the genetic drivers of virulence and the emergence of antimicrobial resistance.

Disciplines and Techniques
Project supervisor/s
Dr. Richard Stabler
Richard's research interests include Clostridium difficile: molecular epidemiology and emergence of hypervirulent isolates & Methicillin resistant Staphylococcus areus: molecular epidemiology and drug resistance
London School of Hygiene and Tropical Medicine
Professor Damer Blake
Damer has extended his research interests in Eimeria - protozoan parasites with cause the disease coccidiosis in all livestock species, most notably poultry.
Royal Veterinary College
Characterization of water and wildlife strains as a subgroup of Campylobacter jejuni using DNA microarrays
Stabler, R.A.; Larsson, J.T.; Al-Jaberi, S.; Nielsen, E.M.; Kay, E.; Tam, C.C.; Higgins, C.D.; Rodrigues, L.C.; Richardson, J.F.; O’Brien, S.J.; Wren, B.W.
Environ Microbiol 15(8):2371-83; DOI: 10.1111/1462-2920.12111; PMID: 23530835
Prevalence of Type VI Secretion System in Spanish Campylobacter jejuni Isolates
Ugarte-Ruiz, M.; Stabler, R.A.; Domìnguez, L.; Porrero, M.C.; Wren, B.W.; Dorrell, N.; Gundogdu, O
Zoonoses Public Health 62(7):497-500; DOI: 10.1111/zph.12176; PMID: 25496466
The impact of Eimeria tenella co-infection on Campylobacter jejuni colonisation of the chicken
Macdonald SE, van Diemen PM, Martineau H, Stevens MP, Tomley FM, Stabler RA, Blake DP
Infection and Immunity. 87:e00772-18.
Illumina next generation sequencing for the analysis of Eimeria populations in commercial broilers and indigenous chickens
Hinsu AT, Thakkar JR, Koringa PG, Vrba V, Jakhesara SJ, Psifidi A, Guitian J, Tomley FM, Rank DN, Raman M, Joshi CG, Blake DP
Frontiers in Veterinary Science. 5:176
Microbial diversity and community composition of caecal microbiota in commercial and indigenous Indian chickens determined using 16s rDNA amplicon sequencing
Pandit R, Hinsu AT, Patel NV, Koringa PG, Jakhesara SJ, Thakkar JR, Shah TM, Limon G, Psifidi A, Guitian J, Hume DA, Tomley FM, Rank DN, Raman M, Tirumurugaan KG, Blake DP, Joshi CG
Microbiome. 6:115