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Computational Study of Prenatal and Postnatal Brain Morphometry Associations with Cognitive Control across the Lifespan

Iroise Research Image

Inhibitory control allows us to control our attention, behaviour, thoughts and emotions to avoid automatic, dominant responses and instead do what is needed in a particular situation. Emerging evidence suggests that asymmetries in brain structure emerging early in development are stable and predict inhibitory control skills in childhood and adulthood. We aim to further investigate how fixed (sulci morphometry, cortical surface area) vs. plastic (local white matter volume and cortical thickness) aspects of brain structure may specifically constrain inhibitory control across development by analysing the morphometry of structural magnetic resonance images (sMRI) of existing child, adolescent and adult cohorts.

Disciplines and Techniques
Project supervisor/s
Dr. Iroise Dumontheil
Iroise's research examines social and executive functions in adulthood and their development during adolescence.
Birkbeck University of London
Professor Robert Leech
Robert's research is inherently multi-disciplinary, integrating neuroscience, psychology and computer science to better understand the healthy and pathological brain.
King's College University
Longitudinal stability of the folding pattern of the anterior cingulate cortex during development
Cachia, A., Borst, G., Tissier, C., Fisher, C., Plaze, M., Gay, O., … Raznahan, A.
Developmental Cognitive Neuroscience, 19, 122–127
Prenatal growth in humans and postnatal brain maturation into late adolescence
Raznahan, A., Greenstein, D., Lee, N.R., Clasen, L.S., Giedd, J.N.
Proceedings of the National Academic of Sciences USA, 109, 11366–11371
Individual differences in anterior cingulate/paracingulate morphology are related to executive functions in healthy males
Fornito, A., Yücel, M., Wood, S., Stuart, G. W., Buchanan, J.-A., Proffitt, T., … Pantelis, C.
Cerebral Cortex, 14(4), 424–4
Sulcal polymorphisms of the IFC and ACC contribute to inhibitory control variability in children and adults
Tissier, C., Linzarini, A., Allaire-Duquette, G., Mevel, K., Poirel, N., Dollfus, S., … Cachia, A.
ENeuro, 5(1)
Executive functions
Diamond A.
Annual Review of Psychology, 64,135–168