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Nils Korte: Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease

kdk
Reduced brain blood flow is one of the earliest events in Alzheimer's and may reflect pericytes constricting capillaries in response to Aβ.

This deprives the brain of energy (in the form of oxygen and glucose in the blood), which triggers a positive feedback loop by upregulating the BACE1 enzyme that makes Aβ.

Preventing capillary constriction early in Alzheimer's (before irreversible damage has occurred) may provide a new therapeutic approach for Alzheimer's - we propose several biomarkers and therapeutic targets in our review.

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