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Gregory Milne: Toward Improving Interventions Against Toxoplasmosis by Identifying Routes of Transmission Using Sporozoite-specific Serological Tools

Horizontal transmission of Toxoplasma gondii occurs primarily via ingestion of environmental oocysts or consumption of undercooked/raw meat containing cyst-stage bradyzoites.

Evidence of exposure to the apicomplexan protozoan parasite Toxoplasma gondii, a cousin of the malaria parasite, is found in approximately 1 in 3 people globally. Infection is horizontally acquired by eating undercooked/raw meat containing cyst-stage bradyzoites, or ingesting environmental oocysts (containing infectious sporozoites), which contaminate crops and water sources. The relative importance of these two routes in different settings remains unclear.

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