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Claudia Sisa: Mesenchymal Stromal Cell Derived Extracellular Vesicles Reduce Hypoxia-Ischaemia Induced Perinatal Brain Injury
In this paper we tested the therapeutic efficacy of mesenchymal stromal cell derived extracellular vescicles (EVs) in neonatal hypoxia-ischemia (HI) brain damage. Our findings show that the intranasal administration of EVs in a mouse model of HI reduced the volume loss, cell death and microglia activation compared to control
littermates.
littermates.
Neonatal hypoxic-ischemic (HI) insult is a leading cause of disability and death in newborns, with therapeutic hypothermia being the only currently available clinical intervention. Thus there is a great need for adjunct and novel treatments for enhanced or alternative post-HI neuroprotection. Extracellular vesicles (EVs) derived from mesenchymal stromal/stem cells (MSCs) have recently been shown to exhibit regenerative effects in various injury models.
Here we present findings showing neuroprotective effects of MSC-derived EVs in the Rice–Vannucci model of severe HI-induced neonatal brain insult. (Click here to read full publication)