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Alice Denyer: Genetics of canine diabetes mellitus part 1: Phenotypes of disease
Unravelling the genetic basis of complex diseases such as diabetes mellitus (DM) is an important and significant challenge for human and veterinary medicine.
Whilst it might not be possible to remove the risk of a disease with a complex genetic basis from a particular population, understanding the genes and mechanisms responsible for an individual’s susceptibility may reveal new drug targets for treatment or prevention of disease.
Breed differences in susceptibility to DM in dogs indicate that genetic factors are likely involved in disease susceptibility (Davison et al., 2005, Fall et al., 2007, Catchpole et al., 2013, Mattin et al., 2014, Heeley et al., 2020) and new genotyping technologies are being employed to demonstrate more precisely which genetic factors are important.
New high-throughput sequencing technologies, which have been invaluable in the study of human DM, hold great potential for research into the genetics of canine DM.