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Project Title Primary Supervisor Secondary Supervisor Actions
Development of novel gene therapy capsids to target astrocytic cells within the central nervous system Killian Hanlon
How is membrane integrity maintained? Adrian Isaacs
Temporal fluctuations in autonomic nervous system activity in the human fetus and neonate Dr Kimberley Whitehead Dr Manasi Nandi
Deciphering the activation mechanism of an evolutionary conserved antiviral response for developing ground-breaking antiviral therapeutics Dr Kourosh H. Ebrahimi Prof Harris Makatsoris
Experimental and mathematical modelling of stem and progenitor cell fate in ageing haematopoiesis. Benjamin Werner
Promoting neurogenesis in the mature brain using designer bioactive nanostructures Professor Francesca Cordeiro
Structure and mechanism of molecular machines involved in the spread of antibiotic resistance genes among bacterial populations Brian Ho
Dissecting the molecular principles of mouth regeneration in animals at single-cell resolution Chema Martin Inês Sequeira
Investigating novel mechanisms of genetic and epigenetic stability at the replication fork David Michod
Developing a gene expression classifier to identify new mechanisms promoting health in old age Maria Secrier
Examining the influence of early life stress on touch perception Sandrine Geranton
Targeting CoaBC from the Coenzyme A pathway of Mycobacterium tuberculosis with radically novel metal-based scaffolds Jeannine Hess Miraz Rahman
Statistical shape models of cardiac anatomy in children born to women with obesity – Children of UPBEAT Paul D. Taylor
The role of breathing variability in health and disease: innovative technology to study and restore efficacious respiratory function. Philippa Warren
Inferring infectious disease transmission from viral genomics and modelling Katie Atkins Stéphane Hué
Investigating the Neural Mechanisms of Mammalian Path Integration Daniel Bush Neil Burgess
Localise to Network: Understanding local protein synthesis with an innovative bioengineered model of complex neural circuitry. Jernej Ule Andrea Serio
Phosphoregulation of YBX1 DNA binding activity is a driver of cellular reprogramming Filippo Prischi Dr Radu Zabet
Determining the relationship between TFEB and the NSL complex in relation to the regulation of mitophagy Helene Plun-Favreau Mina Ryten
How does obesity reprogramme the nucleus? A multi-omics approach. Joseph Burgoyne
Understanding the molecular details of the mitogen activated kinase p38 alpha autoactivation reaction to design allosteric inhibitors of its activity. Franca Fraternali
Interrogating the Interplay of Iron Metabolism and Mitochondrial Function in Human CD8 T cells Alessio Vagnoni
Organ-chip models of bone health and ageing to study the impact of air pollution and systemic inflammation Prof Martin Knight Dr Stefaan Verbruggen
Role of adaptive myelination in spatial memory Guifen Chen
Defining the PAK4 interactome in immune cell adhesion claire.wells Sasi Conte
Engineering artificial cell-like systems to deliver genetic therapies to the brain. Claudia Contini
Investigating the roles of endogenous retrovirus as long non-coding RNAs in human trophoblast Lovorka Stojic
Dissecting the functional role of non-coding transcripts in cellular senescence using state-of-the-art Explainable Artificial Intelligence and omics Radu Zabet
Nanomaterials for cancer imaging Professor Elnaz Yaghini
Multimodal Modelling of Pain, Sensitivity and Endogenous Control Mechanisms: In Life and Laboratories Dr Joseph Barnby
The biomechanics of horns and headbutting in Soay sheep Philip Cox Mehran Moazen
Exploring tendon ageing with novel tendon-chip models Himadri Gupta
Development of antibody imaging conjugates to understand interaction of immune cells and bacterial infection. Vijay Chudasama
Identification of novel vaccine candidates against coccidiosis through immunopeptidomics Dong Xia
Dissecting the molecular pathways of Plasmodium falciparum gametogenesis using phenotypic screening and molecular studies Michael Delves Serge Mostowy
Developing keratin-based scaffolds for soft tissue augmentation Dr Emily Lu
Ageing at the crossroad: new approaches to study cell autonomous and non-cell autonomous effects of mitochondrial dysfunction during neuromuscular ageing. Alessio Vagnoni Yung-Yao Lin
Visualising neuromodulation in vivo Francesco Gervasio
Prophylactic and therapeutic use of phage endolysins Professor Joanne Santini Professor Saul Purton
New single-cell transcriptomics approaches for understanding the role of post-transcriptional regulation in brain development Eugene Makeyev
Deep learning approaches for deciphering cellular interactions from image data Claire Wells
Building smarter foods: Nanoparticles for oral delivery of nutritional supplements. Andrew Surman Balazs Bajka
Frogs as a model for upper limb control and bio-inspired robotic arms Richard Bomphrey
Automated mapping of climate change and associated disease risk: A global methodology for predicting climate-associated disease outbreaks Jennifer Cole
Investigating the role of metabolism in inner ear development using fluorescence lifetime imaging microscopy and genetically encoded biosensors Zoe Mann
Neocortical codes for nociception Matteo Carandini
Developing a platform for the biocatalytic production and characterization of the metabolic products of illicit synthetic cannabinoids Vincenzo Abbate
Improving image processing and data analysis in the study of metabolism in living tissues using advanced fluorescence techniques Thomas Blacker
Agent-based simulations and in vitro models to study the role of bacterial cell-cell interactions on microbial communities Harry McClelland
The effect of lysosomal dysfunction and sigma-1 receptor modulators on membrane contact sites and sigma-1 receptor localisation Emily Eden
Permeability and delivery of ionophores across biological barriers Driton Vllasaliu
Computationally aided design of next generation drug delivery materials Alex Brogan Micaela Matta
Feeding the Algorithms: shedding light on melanin’s dark secrets with advanced analytical tools, molecular modelling and machine learning Micaela Matta Andrew Surman
Investigating heterogeneous immune responses within a human skin-on-chip model of inflammation John Connelly Clare Bennett
Edible Scaffolds for Cultivated Meat Produced from Waste Derived from the Brewing Industry Richard Day Jack Jeffries
Investigating the role of ECM mechanics during tissue development and wound repair Yanlan Mao
Whole-brain single-cell transcriptomics of neuroendocrine gene regulatory networks that link diet to ageing Marcela Lipovsek
Defining order and disorder in protein-RNA interactions Konstantin Roeder Sasi Conte
The infuence of diet on evolution of human metabolism revealed by artificial intelligence and verified by cell biology Matteo Fumagalli
Cognitive computations in sensory areas of the brain Velia Cardin Szonya Durant
Artificial intelligence (AI)-enhanced label-free stem cell sorting for biomedical research Mads Bergholt
Understanding how ageing perturbs muscle stem cell behaviour using a combined in vivo imaging and computational approach Yanlan Mao
Unravelling the molecular basis of proteolytic activation of neuronal calcium channels: a promising target for pain therapy Matthew Gold
Musk odorants and their binding to human musk receptors Franca Fraternali
Super-resolution microscopy of functional synaptic vesicle pools Laura Andreae Susan Cox
Determinants of T-cell cross-immunity in human and animal viruses Leo Swadling
Systems analysis of robustness mechanisms in collective cell migration Mie Wong Philip Pearce
Evolution and regulation of fungal pathogenicity chromosomes: A combined -omics approach. Laurence Bindshedler
Understanding multiregional neural computations by interrogating the cerebellum’s influence on motor cortical activity during goal-directed behaviour Professor Robert Hindges
Understanding changes in brain shape in the developing human brain. Yanlan Mao
Feature selection and cue combination in our probabilistic sensory world: A machine learning and neuroimaging approach Bradley Love
Investigating placental function as a mechanistic link between maternal diet and fetal cardiovascular development Andrew Melbourne
Vanishing giants: understanding the ecological and evolutionary impacts of losing the largest crocodilians through biomechanical analyses David Hone
Dissecting the logic of gene circuitries in the brain and pancreas: common origin or convergence? Benedikt Berninger
“Exploring the boundaries in mechanobiology: the effect of mechanical forces on cellular lipid membranes and organelles” Sergi Garcia-Manyes Ulrike Eggert
Surviving without your support group: Exploring how changes in the glial proteostasis network underlie age-related neuronal dysfunction Maria Jimenez-Sanchez
Understanding non-host resistance in plants: why some plants are attacked by insects but others are not. Rekha Swamy
Developmental controls of sex-biased gene expression and disease susceptibility in the brain Eugene Makeyev
Roles of energy metabolism in cellular stress resilience, longevity and ageing Jürg Bähler Snezhana Oliferenko
Reservoirs of resistance: the effect of ecological variation on the evolution of antimicrobial resistant bacteria Gemma Murray Gwen Knight
The response of brain lymphatic endothelial cells (BLECs) to the infection of brain tissue; a zebrafish project Thomas Hawkins
The development of broadly neutralising anti-influenza nanobodies in preparation for future pandemics. Tracey Barrett Yasu Takeuchi
Constitutive activation of IKK (inhibitor of NFkappaB kinase) a master-regulator of inflammation and cell survival Tracey Barrett
Functional disulfide bridging to infer new properties on antibody bioconjugates Jamie Baker Michelle Ma
Mechanism of a viral anticancer protein Mahvash Tavassoli
Shining a light on skin pigmentation to create biomimetic vesicles for gene delivery Chris Morris Helen Hailes
Investigating human evolution by excavating the genomes of past human populations embedded in large-scale sequencing datasets Garrett Hellenthal Matteo Fumagalli
Optimising a bioactive ECM hydrogel to facilitate stem cell delivery in traumatic brain injury Aminul Ahmed James Phillips
The evolution of mutualistic interactions and of aggregated dispersal Professor Vincent Jansen Professor Andrew Pomiankowski
A Tale of Two Axons: Evaluating Axon Organelle Biology in Healthy CNS Axons and Regenerative PNS axons Richard Eva Jeremy Carlton
improving crop productivity through seed photosynthesis Gerhard Leubner
Understanding seasonal change in vector-borne disease risk for livestock and humans within arid habitats of Northern Kenya Kris Murray
Molecular "death signatures" in Drosophila melanogaster Hrvoje Augustin Stuart Snowden
Mitochondrial transplantation: maintaining bioenergetic homeostasis following cellular stress Richard Southworth
Building physics-informed neural networks to bridge the gap from micro- to macro- modelling of human cortical folding development Katie Long
Characterising the molecular signatures underlying inter-individual variability in response to diet Sarah Berry
Novel mechanistic understanding of ageing in metabolism via integrative epigenomic and functional analysis in human endocrine organs Christopher Bell Paul Caton
Building complex organs: an interdisciplinary approach for ear formation Andrea Streit Alessandra Vigilante
Evolution of eggshell surface structure and physiology Steve Portugal Ryan Felice
Resolving the role of seasonally fluctuating balancing selection in maintaining adaptive genetic diversity in wild butterfly populations Aida Andrés
Understanding the mechanistic link between transfer RNA (tRNA) regulation and biological ageing Michelle Holland Christopher Bell
Understanding bacteriophage driven evolution of antibiotic resistance in Klebsiella pneumoniae Gwen Knight
A duel approach using CRISPR mediated capture with computational multi-‘omics to identify proteins driving alternative polyadenylation Franca Fraternali
Understanding antimicrobial treatment response: rational design of antibiotic combination treatment Frank Kloprogge Dimitrios Evangelopoulos
Molecular organisation of the early secretory pathways by cryo-CLEM Theresa Ward
Dissecting the role of the tissue microenvironment in the regulation of cell competition Susana Godinho
Applications of ene reductases to generate chiral fluorinated compounds and in enzymatic cascades Jack Jeffries
A deep-network exploration of multi-modal spatial responses in the ferret brain Jennifer Bizley
How does the sound environment of laboratory mice affect brain development and animal behaviour? Jennifer F. Linden Charlotte Burn
Exploring the impact of chromosomal instability in early stage retinal organoids and embryoid bodies Jacqui Spuy
Individual differences in the mechanisms underlying expression recognition John Greenwood
Human evolution through genetic adaptation: using ancient DNA to understand how humans colonised the world. Aida Andres Garrett Hellenthal
Investigating novel mechanisms of cell-autonomous immunity: ESCRTs to the rescue of Shigella infected cells Serge Mostowy
Towards an autonomous in silico researcher: Can we automate scientific discovery? Conrad Bessant Pedro Cutillas
The Neurometabolism of inhibitory control in toddlers and preschoolers Tim J. Smith Paola Pinti
The role of the chromatin reader and HUSH-complex component, MPP8 in autoimmunity Myles Lewis
How do cells decode complex inputs to make decisions? Chris Barnes
Investigation of input-output specificity in neurons using protein proximity labelling Andrew Macaskill
Developing innovative models for Angelman Syndrome research analysing cell signalling and development Prof Robin SB Williams Dr Christopher Wilkinson
Sexual selection, meiotic drive and extinction Andrew Pomiankowski Aida Andres
Functional Characterisation of the Campylobacter jejuni Type VI Secretion System (T6SS) Brian Ho
Linking modelling and experimentation to identify the rules of neuronal growth and connectivity. Karen Page Laura Andreae
Air pollution and extreme high temperature risks to rice productivity Huiyi Yang Dabo Guan
Computational and experimental analysis of the role of ageing hallmarks in age-related frailty Karoline Kuchenbaecker Linda Partridge
Probing the energy costs and metabolic trade-offs of the Warburg effect Snezhana Oliferenko Aleksej Zelezniak
Investigating the role of phenylpropanoid pathway genes in resistance to cassava brown streak virus Maruthi Gowda
Molecular mechanisms of FUZZY variants in skull development Karen Liu
Quantitatively understanding microbial community robustness Weini Huang
Regulation of the septin cytoskeleton during cell division ulrike.eggert Guillaume Charras
A Synthetic Biology approach to the exploitation of non-conventional yeasts for the sustainable production of valuable chemicals Paul Fraser Barry Panaretou
Combining experimental and computational approaches to improve local delivery of compounds for nerve regeneration Rebecca Shipley
Combining ultra-high field 7 Tesla fMRI and computational models to investigate the neural basis of conscious awareness Stephen Fleming Peter Kok
Predictive value of brain and behavioural data in early development Frantisek Vasa
Mechanistic basis of force generation by the mitotic motor CENP-E Sarah McClelland
Regulation of neurotransmitter release and synaptic plasticity by vesicle-associated membrane protein 2 (VAMP2) Dimitri Kullmann Kirill Volynski
Unveiling the Molecular Mechanisms of Ultra Long-Range Electron Transport in Bacteria through Multiheme Protein Complexes Ismael Diez Perez Jochen Blumberger
Studying the role of mitochondrial function in cell fate determination Chris Thrasivoulou
Multisensory solutions to the challenge of flight control in locusts Richard Bomphrey
Understanding and exploiting microbial machines - towards antibiotic discovery Rachael Dickman
Understanding the quiet fighters: Making co-cultures work for industrial biotechnology Gary Lye
Assembly and plasticity of cortical circuitries during early life Fursham Hamid
Evolution of neuropeptide signaling: finding the missing links Paola Oliveri
Comparative aspects of viral coinfections on mastitis and milk secretion Professor Suzanne Filteau
Development of targeted antivirals as a strategy for pandemic preparedness against respiratory viruses. Miraz Rahman Mark Sutton
PK/PD assessment of Trimethoprim/Sulfonamide exposure can inform optimal dosage regimen to minimise selection of resistant bacteria in animals Ludovic Pelligand Anjum, Muna
Role of H4K16ac in the regulation of transposable elements in the human brain Radu Zabet
Unravelling the genetics of physiological responses to diet Nazif Alic
Defining the molecular determinants of virulence in bacteria that cause tuberculosis Irene Nobeli
Pattern separation in the cerebellar cortex Claudia Clopath
The role of vimentin in tissue fluid-to-solid phase transitions Guillaume Charras Alessandro Mongera
Building synaptic release machinery in regenerating cells Marcela Lipovsek Matthew Grubb
Integration of structural mass spectrometry and computational methods for the study of early protein misfolding events Franca Fraternali
Deciphering the role of Lamin ribonuclear bodies in skin barrier function and ageing, assessing the function of a new organelle Kevin Mills
The genetics architectures of blood cell traits across diverse African populations Karoline Kuchenbaecker
Targeting DNA’s Secret Secondary Structures Lesley Howell
Exploring developmentally-induced hyperexcitability as a cause for disordered adult social behaviour in a mouse model of neurodevelopmental disorder Helen Stolp Jonathan O’Muircheartaigh
Integrating genomics, metagenomics, and epidemiological data to develop novel tools to reduce the risk of zoonotic outbreaks Dr Androniki Psifidi Prof Damer Blake
How is rhoptry secretion controlled in apicomplexan parasites? A molecular comparative biology study. Ellen Knuepfer Robert Moon
Predicting Single-Cell Nanoneedle Transfection by AI Analysis of Cell Biophysics Thomas Iskratsch
Artificial Intelligence-Driven Synthetic Genomics: Leveraging Deep Generative Networks for Efficient Genome Engineering and Enhanced Organism Design Snezhana Oliferenko
Informing the statistical examination of shared genetic loci with functional genomics to unravel the underlying biological mechanisms Dr Petroula Proitsi
Understanding B cell response to vaccination: Integrating transcriptomics and proteomics data. Kostantinos Thalassinos
Monitoring wild animal virus diversity and transmission in changing environments. Jayna Raghwani
Metabo-lipidomic imaging of neural stem cell cultures Andrea Serio
Retinoic acid signalling in retinal homeostasis and ageing Gaia Gestri
Understanding glial cell sensing and shape changing feedback during morphogenesis by integrating simulations and in vivo zebrafish experiments Ryan MacDonald
How forces and signals combine when neural crest cells migrate, tested using a combination of microscopy, modelling and deep learning Robert Insall
Development of novel fluorophores to detect real-time protein dynamics Thomas Kampourakis
Artificial intelligence algorithms to detect signals of adaptation from genomic data Max Reuter
Investigating the interplay of sterol biosynthesis and mitochondrial metabolism Barrie Peck Gyorgy Szabadkai
Discovering novel phages and exploiting their therapeutic and diagnostic potential Richard Stabler
Studying convergent evolution in wild and domestic animals to find novel mutations affecting the cardiovascular physiology Denis Larkin Caroline Pellet-Many
Mechanical and metabolic control of limb morphogenesis Alessandro Mongera
The role of Chandelier cells in cortical circuit dynamics Adil Khan
The emergence of the genetic code in autotrophic protocells at the origin of life Prof Andrew Pomiankowski
Targeting i-motif DNA structures: characterising the factors that influence i-motif stability Zoё Waller
Chasing a shifting target: The dynamic nature of mycobacterial transcriptomes studied with new sequencing technologies and computational methods Irilenia Nobeli Sharon Kendall
Understanding the constraints on photosynthetic membrane function through computational modelling and experiment Conrad Mullineaux Christopher Duffy
Modelling Dendritic Integration of Sensory Modalities in Periaqueductal Gray (PAG) Neurons during Escape Initiation Maneesh Sahani
Haustoria-omics of powdery mildew diseases infecting food crops to unravel cross-species factors regulating fungal virulence and promoting host susceptibility. Andrew Armitage
Development and function of left-right asymmetry in the brain Isaac Bianco
3D Receptor spatial signalling Paul Fromme
Dissecting nanoscale extracellular matrix interactions promoting cellular senescence with age Himadri Gupta
The emergence of cognitive control in connectionist models of category learning Bradley Love
Deciphering the endogenous mechanisms of anti-tuberculosis action and resistance reversal potential of immune-modulatory drugs. Professor Sanjib Bhakta Professor Helen C. Hailes
The neural bases of time and duration processing in Drosophila Elisabetta Versace
Live analyses of cardiac specification and morphogenesis. Jamie Dean
Deciphering cochlear dynamics: Hyperspectral FLIM to investigate metabolic impact on frequency specific auditory hair cell development Zoe Mann
Resolving the cellular basis of spiralling and morphogenesis in the developing cochlear duct Dan Jagger
Decoding host cell invasion of Theileria parasites using CRISPR/Cas9 gene modification technologies Ellen Knuepfer
Characterisation of serine metabolism in single cells and at the sub-cellular level. Katiuscia Bianchi Gyorgy Szabadkai
The Gravity Prior: Neurocognitive mechanisms of gravitational representation from early stages of life. Elisa Ferré
Investigating Neurodevelopment with Advanced Diffusion Imaging in Animal Models Marija-Magdalena Petrinovic
The synaptic basis of learning and attention Adil Khan Juan Burrone
Exploring evolutionary trade-offs of antimicrobial persistence Brian Ho
Tools for studying transmembrane movement of bicarbonate Cally Haynes
A multiscale approach to unravel the working mechanisms of molecular rotors for bioimaging Klaus Suhling
The impact of Apicomplexan’s MEP pathway on gene regulation and behaviour of the host Frances Hawkes
Mitochondrial specialism in sensors and motors Dr Joerg Albert
Differential attraction of malaria- transmitting mosquitoes to human and non-human primates Frances Hawkes
The impact of host blood sex and density on Anopheles fitness and their capacity to transmit diseases S. Noushin Emami
Faces in the clouds: The neurocomputational basis of agency detection Mitul Mehta
Using genomics to understand vector-pathogen interactions and disease transmission Taane Clark
Understanding molecular evolution of drug resistance in key Mycobacterium drug targets using multiplex saturation mutagenesis and computational modelling Richard Wall
Engineering Seed Microbial Communities to Achieve Forest Recovery Goals Paul Devlin
Modelling the role of metacognition in child learning and decision making Tessa Dekker
Uncovering the structure of neural object representation with model-based fMRI Ulrike Hahn
Optimism biases in human learning and decision making Jonathan Roiser
Functional characterisation the Arf-Src G-protein-tyrosine kinase signalling nexus. Alex Fedorec