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Unveiling the Molecular Mechanisms of Ultra Long-Range Electron Transport in Bacteria through Multiheme Protein Complexes

Full Research Image Unveiling the Molecular Mechanisms of Ultra Long-Range Electron Transport in Bacteria through Multiheme Protein Complexes

Nature has developed unique ways to translocate electrons along exceedingly long distances by designing unique supra-molecular structures that act like “electrical wires”. The efficiency of electron transport in such systems surpasses any current understanding of the physical transport mechanisms in synthetic chemical systems. This project will focus on the study of the molecular basis that accounts for the observed long-range electron transport in some species of Shewanella bacteria used to efficiently pump electrons out towards the extracellular domain using multiheme cytochromes. To this aim, the project proposes a unique biophysical approach that combines cutting-edge single-protein transport experiments with state-of-the-art computational modelling.

Disciplines and Techniques
Project supervisor/s
Dr. Ismael Diez Perez
Ismael is interested in understanding charge transport in synthetic as well as biological molecular architectures at the nanoscale.
King's College London
Professor Jochen Blumberger
Jochen is interested in the development and application of quantum and classical molecular simulation methods to study redox and charge transfer reactions in biological systems, organic semiconductors.
University College London
Journal of Bioenergetics and Biomembranes
Christopher C. Moser, Christopher C. Page, Ramy Farid, P. Leslie Dutton
Journal of Bioenergetics and Biomembranes
Long-distance electron transport in individual, living cable bacteria in Volume 115, 5632-5634
Gemma Reguera
Why are DNA and protein electron transfer so different?
David N. Beratan
Annu. Rev. Phys. Chem., Volume 70, pp 71–97.
Going the Distance: Long-Range Conductivity in Protein and Peptide Bioelectronic Materials
Nicole L. Ing, Mohamed Y. El-Naggar, Allon I. Hochbaum
J. Phys. Chem. B, pp 10403−10423
Nano Bioelectronics
Anqi Zhang, Charles M. Lieber
Chem. Rev. Volume 116, pp 215-257
Structural modeling of an outer membrane electron conduit from a metal-reducing bacterium suggests electron transfer via periplasmic redox partners
Edwards, M. J., White, G. F., Lockwood, C. W., Lawes, M. C., Martel, A., Harris, G., Scott, D. J., Richardson, D. J., Butt, J. N., Clarke, T. A
Journal of Biological Chemistry, Volume 293, pp 8103-8112
Membrane spanning electron transfer proteins from electrongenic bacteria: Production and Investigation
N., Clarke, T. A.
Journal of Biological Chemistry, Volume 293, pp 8103-8112
Conductance Switching in Single Wired Redox Proteins
Juan M. Artés, Montserrat López‐Martínez, Ismael Díez‐Pérez, Fausto Sanz, Pau Gorostiza
Small, Volume 10 pp 2537-2541
Single Protein Molecule Mapping with Magnetic Atomic Force Microscopy
Andriy V. Moskalenko, Polina L. Yarova, Sergey N. Gordeev, Sergey V. Smirnov
Biophys. J. Volume 98, pp 478–487
Bioengineering a Single-Protein Junction
Marta P. Ruiz, Albert C. Aragonès, Nuria Camarero, J. G. Vilhena, Maria Ortega, Linda A. Zotti, Rubén Pérez, Juan Carlos Cuevas, Pau Gorostiza, Ismael Díez-Pérez
JACS Volume 394, pp 15337-15346
Direct evidence for heme-assisted solid-state electronic conduction in multi-heme c-type cytochromes
Garg et al.
Chem. Sci. Volume 9, 7304
Adsorption of Amino Acids on Gold: Assessing the Accuracy of the GolP-CHARMM Force Field and Parametrization of Au–S Bonds
Z. Futera, J Blumberger
J. Chem. Theor. Comput. Volume 15, 613-624
Manuscript in preparation
Futera et al.