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Haustoria-omic of powdery mildew fungi infecting cereals, pea, and strawberry to unravel key factors of biotrophy, susceptibility and virulence

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Powdery mildew diseases (PMs), caused by obligate biotrophic fungi, compromise food production. PMs affect major crops, including cereals, legumes, cucurbits, strawberry. PM biotrophic interaction with their host completely rely on haustoria that are confined to the infected leaves epidermis, while hyphae grow “outside” the host, epiphytically. Comparative proteomics and transcriptomics analysis of haustorial and extrahaustorial structures from different PMs (barley, wheat, pea, strawberry) will identify the haustorium core protein candidates required for plant susceptibility and fungal virulence. While these pathogens cannot be genetically transformed, a transient gene silencing assay will allow to validate gene functionality for infection.


Disciplines and Techniques
Project supervisor/s
Laurence Bindschedler
Biological Sciences (
Royal Holloway University London
Dr Andrew Armitage
Agriculture, Health and Environment (
Natural Resources Institute (NRI) University of Greenwich
Analysis of barley leaf epidermis and extrahaustorial proteomes during powdery mildew infection reveals that the PR5 thaumatin-like protein TLP5 is required for susceptibility towards Blumeria graminis f.sp. hordei
Lambertucci S.; Orman K.M.; Das Gupta S.; Fisher J.P.; Gazal S.; Williamson R.J.; Cramer R.; Bindschedler L.V.
Frontiers in Plant Sciences
Proteogenomics and in silico structural and functional annotation of the barley powdery mildew Blumeria graminis f. sp. hordei
Bindschedler L, McGuffin LJ, Burgis TA, Spanu PD, Cramer R.
Methods. 54: 432-41
Mildew-omics: How global analyses aid the understanding of life and evolution of powdery mildews
Bindschedler L, Panstruga R, and Spanu PD
Front. Plant Sci. 7:123
Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics
Bindschedler L, Palmblad M, Cramer R.
Phytochemistry 69:1962-72
Identification of powdery mildew resistance QTL in strawberry (Fragaria× ananassa)
Cockerton, H. M., Vickerstaff, R. J., Karlström, A., Wilson, F., Sobczyk, M., He, J. Q. & Harrison, R. J.
Theoretical and applied genetics, 131(9), 1995-2007