Creating Novel Bio-Adhesives using Genetically Programmed Protein Assembly
We will use genetically programmed intein-mediated protein ligation to assemble specific protein modules from molluscs/bacterial biofilms into novel adhesive fibres and gels. This will be achieved by combining our exclusive/innovative recombinant fusion protein system and our knowledge on bacterial biofilm/mollusc adhesion proteins. Utilising the recombinant fusion protein system, we will be able to directionally self-assemble protein modules into the desired bio-adhesive. By combining fusions correctly, predictable arrays of adhesive fibres and gels will be formed with controllable properties/architectures. This technology offers a low-cost highly tuneable platform technology to produce novel adhesives.